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2009 1

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DNA methylation 1

calvarium 1

child 1

dysplasia 1

epigenetics 1

esophageal cancer 1

fibrous dysplasia 1

monostotic 1

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Fibrous dysplasia involving the calvarium in children?

Chunquan CAI, Qian LI, Qingjiang ZHANG, Changhong SHEN

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 211-215 doi: 10.1007/s11684-009-0024-7

Abstract: gain a broader appreciation of the clinical presentation, operative treatment, and outcome of fibrous dysplasiainvolving the calvarium in children, we retrospectively reviewed a series of cases of fibrous dysplasiaFibrous dysplasia in the series was monostotic, involving frontal bone (2 cases), temporal bone (1 caseAll the cases were histopathologically confirmed as fibrous dysplasia.It was demonstrated thatfibrous dysplasia involving the calvarium is a typically benign but slowly progressive

Keywords： fibrous dysplasia calvarium monostotic child

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic and epigenetic alterations, and leads to the activation of oncogenes and the inactivation or loss of tumor suppressor genes (TSG). In addition to genetic alteration, epigenetic modifications, and in particular DNA methylation, are recognized as a common molecular alteration in human tumors. In esophageal cancer, aberrant methylation of promoter regions occurs not only in advanced cancer, but also in premalignant lesions. DNA methylation is related to survival time and sensitivity of chemoradiotherapy. This review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection for patient prognosis, treatment choices, and potential targeting therapy.

Keywords： epigenetics DNA methylation esophageal cancer dysplasia